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h.pylori and cancer


Rebound Health Series                                                                                2018

- h.pylori -

  • acid reflux
  • Heartburn
  • indigestion

- chronic inflammation -

  • Stomach Ulcers
  • Red Eye Syndrome
  • Nasal Polyps
  • Eosophogeal Polyps
  • Thyroid disorders

    - mucus membrane inflammation -

  • Nasal Cancer
  • Throad cancer
  • Esophageal cancer
  • Stomach Cancer
  • Bowel Cancer
  • MALT Lymphoma
  • [MALT - Mucus Associated Lymphatic Tissue]



Bryon Verhaeghe

 RDID 181567

<< created Sep 16, 2018, needs a lot of work, incomplete >>

H.pylori is a bacteria that travels into our body through the mouth. Usually we are contaminated with undercooked salt water shell fish, raw tomatoes or bean sprouts in salad, and sushi / sushimi. Cooking food with heat kills h.pylori.

The fecal to oral route is common. People should wash their hands well before preparing food in the kitchen. Restarant staff are not always diligent, so just go with cooked meals when eating out.

They attach to the body on mucus membranes.The most common being the eye lid (blepharitis), the mouth, salivary glands, throat, vocal cords, thyroid, esophagus, stomach, intestines and bowel. Once established thay can induce chronic inflammation, heartburn, indigestion, acid reflux and ulcers.

Firstly, they produce an enzyme to neutralize stomach acids, called urase. The stomach fights them by producing more stomach acids to give us heartburn, acid reflux, burping, bloating and indigestion.

Long ago the h.pylori was thought to be rare in humans but now it is considered to colonize more than half the global population with colonization rates the highest in Western countries.

They hang on to mucus membranes with tentacles and produce a biofilm (slime) to protect themselves from acid and white blood cells.

Over time they move away from the stomach acids, the immune mechanism of the stomach, and burough into the inner layer of the mucus membrane, called lumen, to live long term.

Once away from hostile stomach acids they begin to cause tissue damage and an ulcer forms.

After a long time they h.pylori begins to collect and push the medium chain fatty acid called myristic acid into the nearby cells and they begin to hyper grow as a cancerous tumor.

The clasification of cancer is beyond the scope of this article but in general it is the mucus membranes of the body that are susceptable; MALT Lymphoma, Mucus Associated Lympoid Tissue Lymphoma

The MALT Lymphoma is 95% associated with h.pylori and the virulence of this bacteria is based on Myristic acid.  A common fatty acid containing a 14 carbon chain.

Skeletal formula of myristic acid Myristic acid, a medium chaing fatty acid.

High levels are found in coconut oil, palm kernal oil and nutmeg. There is a fair amount in cow's milk and less in human breast milk.

Another common medium chain fatty acid found in coconut milk, palm kernal oil, laurel oil is known as lauric acid. This oil is also found in cow, human and goat's milk. Laurel oil is high in cosmetics, shampoo and soap as sodium-laurel-sulfate (SLS).

Medium chain fatty acids are known to be a risk factor for heart diseases.

Fatty aicds have a chain of carbon atoms:

  • short chain fatty acid (SCFA),           3-5 carbon chain
  • medium chain fatty acid (MCFA,       6-12*
  • long chain fatty acid (LCFA),           13-21*
  • very long chain fatty acid (VLCFA) , 22+

*carbon chains of even numbers are more common in nature, greater stability.

<< fatty acids needs to be a separate article, very long topic >>

<< start of CagA / T4 stub, needs to be relocated >>

The virulence of h.pylori and it's ability to induce cancer is from an enzyme called CagA. The CagA enzyme is part of the Src family of enzyems that disable white blood cells and interfere with the tyrosine related growth factors to induce tumor growth. This also interferes with the thyroid function because the T4 -thyroxine hormone of the thyroid is based on the amino acid called tyrosine. When tyrosine is attached as a side chain to other molecules it is called tyrosyl.

Skeletal formula of the L-isomertyrosine  thyroxine

The ability of h.pylori to upset the tyrosine / thyroxine function may likely be a risk factor in throid disorders.

<< end of CagA / T4 stub >>

Once the h.pylori is established into the marginal layer of the mucus membrane it pushes medium chain fatty acids into nearby cells. This alters the state of the cell and hyper-stimulates defective cellular growth, cancer. The T4 - thyroxine is a stimulative signal as is hyper-thyroidism stimulates heart rate, body temperture and blood pressure.







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